Research Areas
- Infectious Diseases in Changing Environment
- Natural and anthropogenic disturbances in the environment bring about major ecological changes that can promote the transmission of pathogens. Some of the major infectious diseases that are becoming prominent due to environmental change are vector-borne diseases (e.g., dengue, malaria) and waterborne diseases (e.g., rotavirus, cholera, leptospirosis). We implement advanced methodological tools to measure the impact of environmental changes on the incidence of infectious diseases retrospectively or prospectively for the future. Generating such scientific evidence is crucial to support changes necessary to improve the healthcare system and disease control strategies.
- Nottmeyer L, Armstrong B, Lowe R, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM, Lavigne E, Correa PM, Ortega NV, Kynčl J, Urban A, Orru H, Ryti N, Jaakkola J, Dallavalle M, Schneider A, Honda Y, Ng CFS, Alahmad B, Carrasco G, Holobâc IH, Kim H, Lee W, Íñiguez C, Bell ML, Zanobetti A, Schwartz J, Scovronick N, Coélho MSZS, Saldiva PHN, Diaz MH, Gasparrini A, Sera F. The association of COVID-19 incidence with temperature, humidity, and UV radiation – A global multi-city analysis. Sci Total Environ. 2022 Sep 7;854:158636.
- Toizumi M, Satoh C, Quilty BJ, Nguyen HAT, Madaniyazi L, Le LT, Ng CFS, Hara M, Iwasaki C, Takegata M, Kitamura N, Nation ML, Satzke C, Kumai Y, Do HT, Bui MX, Mulholland K, Flasche S, Dang DA, Kaneko K, Yoshida LM. Effect of pneumococcal conjugate vaccine on prevalence of otitis media with effusion among children in vietnam. Vaccine. 2022, 40(36): 5366-5375.
- Nwe KM, Ngwe Tun MM, Myat TW, Ng CFS, Htun MM, Lin H, Hom NS, Soe AM, Elong Ngono A, Hamano S, Morita K, Thant KZ, Shresta S, Thu HM, Moi ML. Acute-phase serum cytokine levels and correlation with clinical outcomes in children and adults with primary and secondary dengue virus infection in myanmar between 2017 and 2019. Pathogens. 2022, 11(5): 558.
- Yasuda I, Suzuki M, Maeda H, Terada M, Sando E, Ng CFS, Otomaru H, Yoshida LM, Morimoto K. Respiratory virus detection in the upper respiratory tract of asymptomatic, community-dwelling older people. BMC Infectious Diseases. 2022, 22: 411.
- Chua PLC, Ng CFS, Tobias A, Seposo XT, Hashizume M. Associations between ambient temperature and enteric infections by pathogen: a systematic review and meta-analysis. Lancet Planetary Health. 2022 Mar;6(3):e202-e218.
- Igaki S, Duc NTM, Nam NH, Nga TTT, Bhandari P, Elhamamsy A, Lotify CI, Hewalla ME, Tawfik GM, Mathenge PG, Hashizume M, Huy NT. Effectiveness of community and school-based sanitation interventions in improving latrine coverage: a systematic review and meta-analysis of randomized controlled interventions. Environ Health Prev Med. 2021;26(1):26.
- Althouse BM, Flasche S, Toizumi M, Nguyen HT, Vo HM, Le MN, Hashizume M, Ariyoshi K, Anh DD, Rodgers GL, Klugman KP, Hu H, Yoshida LM. Differences in clinical severity of respiratory viral infections in hospitalized children. Sci Rep. 2021;11(1):5163.
- Thet Swe K, Mizanur Rahman M, Shafiur Rahman M, Teng Y, Krull Abe SK, Hashizume M, Shibuya K. Impact of poverty reduction on access to water and sanitation in low- and lower-middle-income countries: country-specific Bayesian projections to 2030. Trop Med Int Health. 2021 Jul;26(7):760-774.
- Seposo X, Madaniyazi L, Ng CFS, Hashizume M, Honda Y. COVID-19 pandemic modifies temperature and heat-related illness ambulance transport association in Japan: a nationwide observational study. Environ Health. 2021 Dec 2;20(1):122.
- Yasuda I, Saito N, Suzuki M, Umipig DV, Solante RM, Guzman F, Sayo AR, Yasunami M, Koizumi N, Kitashoji E, Sakashita K, Ng CFS, Smith C, Ariyoshi K. Unique characteristics of new complete blood count parameters, the immature platelet fraction and the immature platelet fraction count, in dengue patients. PLoS One. 2021 Nov 1;16(11):e0258936.
- Onozuka D, Tanoue Y, Nomura S, Kawashima T, Yoneoka D, Eguchi A, Ng CFS, Matsuura K, Shi S, Makiyama K, Uryu S, Kawamura Y, Takayanagi S, Gilmour S, Hayashi TI, Miyata H, Sera F, Sunagawa T, Takahashi T, Tsuchihashi Y, Kobayashi Y, Arima Y, Kanou K, Suzuki M, Hashizume M. Reduced mortality during the COVID-19 outbreak in Japan, 2020: a two-stage interrupted time-series design. Int J Epidemiol. 2022 Feb 18;51(1):75-84.
- Sera F, Armstrong B, Abbott S, Meakin S, O'Reilly K, von Borries R, Schneider R, Royé D, Hashizume M, Pascal M, Tobias A, Vicedo-Cabrera AM; MCC Collaborative Research Network; CMMID COVID-19 Working Group, Gasparrini A, Lowe R. A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries. Nat Commun. 2021 Oct 13;12(1):5968.
- Madaniyazi L, Seposo X, Ng CFS, Tobias A, Toizumi M, Moriuchi H, Yoshida LM, Hashizume M. Respiratory syncytial virus outbreaks are predicted after the COVID-19 pandemic in Tokyo, Japan. Jpn J Infect Dis. 2022 Mar 24;75(2):209-211.
- Chua PLC, Ng CFS, Rivera AS, Salva EP, Salazar MA, Huber V, Hashizume M. Association between ambient temperature and severe diarrhoea in the national capital region, Philippines. Int J Environ Res Public Health. 2021 Aug 2;18(15):8191.
- Madaniyazi L, Ng CFS, Seposo X, Toizumi M, Yoshida LM, Honda Y, Armstrong B, Hashizume M. Role of temperature, influenza and other local characteristics in seasonality of mortality: a population-based time-series study in Japan. BMJ Open. 2021;11(7):e044876.
- Seposo X, Ng CFS, Madaniyazi L. Immediate and delayed meteorological effects on COVID-19 time-varying infectiousness in Tropical Cities. Atmosphere. 2021; 12: 513.
- Tobias A, Madaniyazi L, Ng CFS, Seposo X, Hashizume M. Can SARS-CoV-2 global seasonality determined after one year of pandemic? Environ Epidemiol. 2021;5(2):e146.
- Uryu S, Tanoue Y, Nomura S, Matsuura K, Makiyama K, Kawashima T, Yoneoka D, Eguchi A, Kawamura Y, Gilmour S, Sakamoto H, Shimizu K, Ng CFS, Hashizume M. Trends in emergency transportation due to heat illness under the new normal lifestyle in the COVID-19 era, in Japan and 47 prefectures. Sci Total Environ. 2021;768:144723.
- Kawashima T, Nomura S, Tanoue Y, Yoneoka D, Eguchi A, Ng CFS, Matsuura K, Shi S, Makiyama K, Uryu S, Kawamura Y, Takayanagi S, Gilmour S, Miyata H, Sunagawa T, Takahashi T, Tsuchihashi Y, Kobayashi Y, Arima Y, Kanou K, Suzuki M, Hashizume M. Excess all-cause deaths during coronavirus disease pandemic, Japan, January–May 2020. Emerg Infect Dis 2021;27(3):789-795.
- Amimo F, Lambert B, Magit A, Hashizume M. A review of prospective pathways and impacts of COVID-19 on the accessibility, safety, quality, and affordability of essential medicines and vaccines for universal health coverage in Africa. Global Health. 2021;17(1):42.
- Yoshihara K, Minh LN, Okada T, Toizumi M, Nguyen HA, Vo HM, Hashizume M, Dang DA, Kimura H, Yoshida LM. Evolutionary dynamics of influenza B strains detected from paediatric acute respiratory infections in central Vietnam. Infect Genet Evol. 2020;81:104264.
- Zeka A, Tobias A, Leonardi G, Bianchi F, Lauriola P, Crabbe H, Vardoulakis S, Guo Y, Honda Y, Gasparrini A, Hashizume M, Vicedo AM, Knudsen LE, Sera F, Ashworth M; Scientific Committee of the International Network of Public Health and Environmental Tracking. Responding to COVID-19 requires strong epidemiological evidence of environmental and societal determining factors. Lancet Planet Health. 2020;4(9):e375-e376.
- Amimo F, Lambert B, Magit A, Sacarlal J, Hashizume M, Shibuya K. Plasmodium falciparum resistance to sulfadoxine-pyrimethamine in Africa: a systematic analysis of national trends. BMJ Glob Health. 2020;5(11):e003217.
- Ng CFS, Seposo XT, Moi ML, Tajudin MABA, Madaniyazi L, Sahani M. Characteristics of COVID-19 epidemic and control measures to curb transmission in Malaysia. International Journal of Infectious Diseases. 2020 Dec;101:409-411.
- Hsai NM, Matsui M, Ng CFS, Khaing CT, Imoto A, Sayed AM, Huy NT, Kamiya Y, Moji K. Satisfaction of pregnant women with antenatal care services at women and children hospital in south okkalapa, myanmar: a facility-based cross-sectional study triangulated with qualitative study. Patient Preference and Adherence. 2020 Dec 18;14:2489-2499.
- Nguyen CT, Moi ML, Le TQM, Nguyen TTT, Vu TBH, Nguyen HT, Pham TTH, Le THT, Nguyen LMH, Phu Ly MH, Ng CFS, Takemura T, Morita K, Hasebe F. Prevalence of zika virus neutralizing antibodies in healthy adults in vietnam during and after the zika virus epidemic season: a longitudinal population-based survey. BMC Infectious Diseases. 2020 May 11;20(1):332.
- Shimmei K, Nakamura T, Ng CFS, Hashizume M , Murakami Y, Maruyama A, Misaki T, Okabe N, Nishiwaki Y. Association between seasonal influenza and absolute humidity: time-series analysis with daily surveillance data in Japan. Sci Rep. 2020;10(1):7764.
- Sassa M, Evans A.C, Ngetich B, Cheruiyot, Tanaka M, Moriyasu T, Kaneko S, Sammy M.N, Sharon E.C, Hamano S. Prevalence and risk factors of Schistosoma mansoni infection among children under two years of age in Mbita, Western Kenya. PLOS NeglectedTropical Diseases. 2020 Aug 25;14(8):e0008473.
- Yamakawa M, Tokinobu A, Tanaka Y, Matsushita N, Hashizume M. Missed opportunities for measles vaccination among departing travelers from Japan to India. J Travel Med. 2020 Feb 3;27(1):taz086.
- Matsushita N, Kim Y, Ng CFS, Moriyama M, Igarashi T, Yamamoto K, Otieno W, Minakawa N, Hashizume M. Differences of rainfall-malaria associations in lowland and highland in Western Kenya. Int J Environ Res Public Health. 2019;16(19):3693.
- Kim Y, Ratnam JV, Doi T, Morioka Y, Behera S, Tsuzuki A, Minakawa N, Sweijd N, Kruger P, Maharaj R, Imai CC, Ng CFN, Chung Y, Hashizume M. Malaria predictions based on seasonal climate forecasts in South Africa: a time series distributed lag nonlinear model. Sci Rep. 2019;9(1):17882.
- Onozuka D, Gasparrini A, Sera F, Hashizume M, Honda Y. Modeling future projections of temperature-related excess morbidity due to infectious gastroenteritis under climate change conditions in Japan. Environ Health Perspect. 2019;127(7):77006.
- Toizumi M, Suzuki M, Nguyen HAT, Le MN, Ariyoshi K, Moriuchi H, Hashizume M, Dang DA, Yoshida LM. Viral acute respiratory illnesses in young infants increase the risk of respiratory readmission. Pediatr Infect Dis J. 2018;37(12):1217-1222.
- Althouse BM, Flasche S, Minh LN, Thiem VD, Hashizume M, Ariyoshi K, Anh DD, Rodgers GL, Klugman KP, Hu H, Yoshida LM. Seasonality of respiratory viruses causing hospitalizations for acute respiratory infections in children in Nha Trang, Vietnam. Int J Infect Dis. 2018 Oct;75:18-25.
- Yoshihara K, Le MN, Toizumi M, Nguyen HA, Minh Vo H, Odagiri T, Fujisaki S, Ariyoshi K, Moriuchi H, Hashizume M, Dang DA, Yoshida LM. Influenza B associated paediatric acute respiratory Iinfection hospitalization in central Vietnam. Influenza Other Respir Viruses. 2019 May;13(3):248-261.
- Matsushita N, Ng CFS, Kim Y, Suzuki M, Saito N, Ariyoshi K, Salva EP, Dimaano EM, Villarama JB, Go WS, Hashizume M. The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines. PLoS Negl Trop Dis. 2018;12(4): e0006331.
- Lam HY, Rivera AS, Chua PLC, Lopez JF, Cheng KG, Palasi WA. Cost of hospitalization of different types of schistosomiasis cases in endemic areas in the Philippines: indicating the need to increase the coverage of government health insurance. Acta Medica Philippina. 2018; 52(2):140-146.
- Toizumi M, Nguyen GTH, Motomura H, Nguyen TH, Pham E, Kaneko K, Uematsu M, Nguyen HA, Dang DA, Hashizume M, Yoshida LM, Moriuchi H. Sensory defects and developmental delay among children with congenital rubella syndrome. Sci. Rep. 2017;7:46483.
- Ikeda T, Behera SK, Morioka Y, Minakawa N, Hashizume M, Tsuzuki A, Maharaj R, Kruger P. Seasonally lagged effects of climatic factors on malaria incidence in South Africa. Sci. Rep. 2017;7:2458.
- Imai C, Barnett AG, Hashizume M, Honda Y. The role of influenza in the delay between low temperature and ischemic heart disease: evidence from simulation and mortality data from Japan. Int J Environ Res Public Health. 2016;13(5):454.
- Yoshihara K, Le NM, Okamoto M, Akpeedje WAC, Nguyen HA, Toizumi M, Pham E, Suzuki M, Nguyen ATT, Oshitani H, Ariyoshi K, Moriuchi H, Hashizume M, Dang AD, Yoshida LM. Association of RSV-A ON1 genotype with increased pediatric acute lower respiratory tract infection in Vietnam. Sci. Rep. 2016;6:27856.
- Yoshihara K, Le NM, Nagasawa K, Tsukagoshi H, Nguyen HA, Toizumi M, Moriuchi H, Hashizume M, Ariyoshi K, Dang DA, Kimura H, Yoshida LM. Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein (G) gene in central Vietnam. Infect Genet Evol. 2016;45:437–446.
- Hashizume M, Nakagomi T, Nakagomi O. An early detection of decline in rotavirus cases during the 2013/2014 season in Japan as revealed by time-series analysis of national surveillance data. Trop Med Health. 2015;43(3):177–181.
- Belizario VY Jr, Erfe JM, Naig JA, Chua PLC. Evidence of increasing risk of schistosomiasis among school-age children in the municipality of Calatrava, province of negros occidental, Philippines. Asian Pacific Journal of Tropical Medicine. 2015;8(5):373-377.
- Belizario VY Jr, Marfori RM, Chua PLC, Naig JA, Erfe JM. School-based combined mass drug administration for soil-transmitted helminthiases and schistosomiasis among school-age children: lessons from two co-endemic areas in the Philippines. Asian Pacific Journal of Tropical Disease. 2015;5(5):358-362.
- Imai C, Armstrong B, Chalabi Z, Mangtani P, Hashizume M. Time series regression model for infectious disease and weather. Environ Res. 2015;142:319-327.
- Imai C, Hashizume M. Systematic review on methodology: time series regression analysis for environmental factors and infectious diseases. Trop Med Health. 2015;43(1):1-9.
- Imai C, Brooks WA, Chung Y, Goswami D, Anjali BA, Dewan A, Kim H, Hashizume M. Tropical influenza and weather variability among children in an urban low-income population in Bangladesh. Glob Health Action. 2014;7:24413.
- Belizario VY Jr, Liwanag HC, Naig JA, Chua PLC, Madamba MI, Dahildahil RO. Parasitological and nutritional status of school-age and preschool-age children in four villages in Southern Leyte, Philippines: Lessons for monitoring the outcome of community-led total sanitation. Acta Tropica. 2014;141PA:16-24.
- Belizario VY Jr, Chua PLC, Liwanag HC, Naig JA, Erfe JM. Soil-transmitted helminthiases in secondary school students in selected sites in two provinces in the Philippines: policy implications. Journal of Tropical Pediatrics. 2014;60(4):303-307.
- Dewan AM, Corner RJ, Hashizume M, Ongee ET. Typhoid fever and its association with environmental factors in the Dhaka Metropolitan Area of Bangladesh: a spatial and time-series approach. PLoS Negl Trop Dis. 2013:7(1): e1998.
- Haque U, Glass GE, Bomblies A, Hashizume M, Mitra D, Noman N, Haque W, Kabir M, Yamamoto T, Overgaard HJ. Risk factors associated with clinical malaria episodes in Bangladesh: a longitudinal study. Am J Trop Med Hyg. 2013:88(4):727–732.
- Corner RJ, Dewan AM, Hashizume M. Modelling typhoid risk in Dhaka Metropolitan Area of Bangladesh: the role of socio-economic and environmental factors. Int J Health Geogr. 2013 Mar 16;12:13.
- Hashizume M, Chaves LF, Faruque ASG, Yunus M, Streatfield PK, Moji K. A differential effect of indian ocean dipole and El Nino on cholera dynamics in Bangladesh. PLoS One. 2013:8(3): e60001.
- Sanza M, Totañes FG, Chua PLC, Belizario VY Jr. Monitoring the impact of a mebendazole mass drug administration initiative for soil-transmitted helminthiases (STH) control in the western visayas region of the Philippines from 2007 through 2011. Acta Tropica. 2013;127(2):112-117.
- Erfe JM, Belizario VY Jr, Chua PLC, Naig JR. Validating the WHO dose pole in the Philippines for school-based mass drug administration of praziquantel for morbidity control of schistosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2013;107(10):615-619.
- Chaves LF, Satake A, Hashizume M, Minakawa N. Indian ocean dipole and rainfall drive a moran effect in East Africa malaria transmission. J Infect Dis. 2012:205:1885–1891.
- Haque U, Scott LM, Hashizume M, Fisher E, Haque R, Yamamoto T, Glass GE. Modelling malaria treatment practices in Bangladesh using spatial statistics. Malaria J. 2012:11:63.
- Choi K, Cho S, Hashizume M, Kim H. Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea. PLoS One. 2012;7(10):e47634.
- Onozuka D, Hashizume M. Effect of weather variability on the incidence of mumps in children: a time-series analysis. Epidemiol. Infect. 2011;139:1692–1700.
- Oki M, Sunahara T, Hashizume M, Yamamoto T. Optimal timing of insecticide fogging to minimize dengue incidence: modeling dengue transmission among various seasonalities and transmission intensities. PLoS Neglect Trop Dis. 2011:5(10): e1367.
- Onozuka D, Hashizume M. The influence of temperature and humidity on the incidence of hand, foot, and mouth disease in Japan. Sci Total Environ. 2011;39:95–103.
- Haque U, Hashizume M, Sunahara T, Hossain S, Ahmed SM, Haque R, Yamamoto T and Glass GE. Progress and challenges to control malaria in a remote area of chittagong hill tracts, Bangladesh. Malaria J. 2010;9:156.
- Haque U, Hashizume M, Glass GE, Dewan A, Overgaard HJ, Yamamoto T. The role of climate variability in the spread of malaria in Bangladeshi highland. PLoS One. 2010;5(12): e14341.
- Kuroiwa C, Vongphrachanh P, Xayyavong P, Southalack K, Hashizume M, Nakamura S. Measles epidemiology and outbreak investigation using Igm test in Laos. J Epidemiol. 2001;11:255–262.
- Kuroiwa C, Vongphrachanh P, Chosa T, Murakami H, Hashizume M, Wakai S, Tanaka M. Risk of poliomyelitis importation and re-emergence in Laos. The Lancet. 2000;356:1487–1488.